Understanding how mouse brain cells work together and communicate
Bridging Function, Connectivity, and Transcriptomics of Mouse Cortical Neurons
This study is looking at how different brain cells in mice work together and how their genes affect their job in processing what we see, using special techniques to see how they react to visual information.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Allen Institute NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10883747 on NIH RePORTER |
What this research studies
This research investigates the relationships between different types of brain cells in mice, focusing on how their genetic makeup influences their function and connectivity. By examining the primary visual cortex, the study aims to link specific cell types defined by their gene expression to their roles in processing visual information. The researchers will use advanced techniques like multiplexed fluorescence in-situ hybridization and calcium imaging to observe how these cells respond to visual stimuli. This approach will help clarify how the brain's structure and function are interconnected at a cellular level.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals interested in the genetic and cellular basis of brain function, particularly those with conditions affecting visual processing.
Not a fit: Patients with conditions unrelated to brain function or those not interested in genetic research may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of brain function and potentially lead to new treatments for neurological disorders.
How similar studies have performed: Other research has shown promising results in linking cellular characteristics to brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
Seattle, United States
- Allen Institute — Seattle, United States (Active)
Researchers
- Principal investigator: Arkhipov, Anton — Allen Institute
- Study coordinator: Arkhipov, Anton
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.