Understanding how motor neurons maintain their identity and function
Hox-dependent mechanisms for establishment and maintenance of motor neuron terminal identity
This study is looking at how different types of motor neurons, which help control movement, develop and stay healthy over time, using tiny worms and mice to learn more about the genes involved, with the hope of finding answers that could help people with conditions like ALS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10802193 on NIH RePORTER |
What this research studies
This research investigates the molecular mechanisms that allow different types of motor neurons to acquire and maintain their unique functions throughout life. By studying both the nematode C. elegans and mice, the researchers aim to uncover how specific genes are regulated during development and adulthood. The focus is on understanding the transcriptional regulation of genes that define motor neuron identity, which is crucial for addressing diseases like amyotrophic lateral sclerosis. The findings could lead to new insights into why certain motor neuron subtypes are more susceptible to diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with amyotrophic lateral sclerosis or similar motor neuron diseases.
Not a fit: Patients with motor neuron diseases not related to the specific mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies for motor neuron diseases, improving outcomes for affected patients.
How similar studies have performed: Other research has shown promise in understanding motor neuron biology, but this approach is novel in its focus on gene regulatory mechanisms across different model organisms.
Where this research is happening
Chicago, United States
- University of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Kratsios, Paschalis — University of Chicago
- Study coordinator: Kratsios, Paschalis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.