Understanding how motor neurons change in monkeys with Parkinson's disease
Connectome of Motor Corticofugal Neurons in Parkinsonian Monkeys
This study looks at how Parkinson's disease affects brain cells that control movement in monkeys, helping us learn more about how the condition impacts movement and coordination, which could lead to better understanding and treatments for people with Parkinson's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10930882 on NIH RePORTER |
What this research studies
This research investigates the changes in motor corticofugal neurons in monkeys that have been made parkinsonian through a neurotoxin. By examining the structural and functional alterations in the brain's motor areas, the study aims to uncover how these changes affect movement and coordination. The researchers will analyze the connectivity and activity of neurons in the primary motor cortex and supplementary motor area to better understand the impact of Parkinson's disease on motor function. This work could provide insights into the underlying mechanisms of motor dysfunction in Parkinson's patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who experience motor control issues.
Not a fit: Patients without Parkinson's disease or those with advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for motor dysfunction in Parkinson's disease.
How similar studies have performed: Other research has shown promising results in understanding motor neuron changes in Parkinson's disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Smith, Yoland — Emory University
- Study coordinator: Smith, Yoland
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.