Understanding How Molecules Fold and Assemble to Improve Health
Supramolecular Strategies to Modulate Biomolecular Folding and Assembly
This research explores how tiny molecules in our bodies fold and connect, aiming to find new ways to help them work correctly, especially in conditions like Alzheimer's.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11143275 on NIH RePORTER |
What this research studies
Our bodies rely on molecules to fold and assemble in very specific ways for everything to function properly. When these molecules don't fold correctly, it can lead to various health problems. This project aims to create new synthetic tools that can interact with these natural processes, much like natural 'chaperone' molecules guide proteins to their correct shapes. By understanding and influencing how these molecules behave, we hope to develop new approaches to address diseases caused by misfolded proteins.
Who could benefit from this research
Good fit: This is fundamental laboratory research and does not involve direct patient participation at this stage.
Not a fit: Patients seeking immediate clinical treatments or direct participation in a human trial would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to entirely new ways to prevent or treat diseases linked to incorrect protein folding and assembly, such as Alzheimer's disease.
How similar studies have performed: This research builds upon existing knowledge in chemistry and biology, but it explores novel supramolecular approaches to intervene in complex biological processes.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Partridge, Benjamin Edward — University of Rochester
- Study coordinator: Partridge, Benjamin Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.