Understanding how molecular motors transport cargo in cells
Official title: Molecular motor dynamics underlying bidirectional cargo transport in cells
Funded at Pennsylvania State University, the · NIH-10884191 · Data updated 2026-11-12
This study is looking at how tiny motors in our cells work together to move important materials around, which could help us understand problems that lead to diseases like Alzheimer's and ALS, and hopefully find new ways to treat these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State University, the NIH-funded |
| Lab location | 1 site (University Park, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 5F32GM149114-02 |
| Project ID | NIH-10884191 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with neurodegenerative diseases such as Alzheimer's disease or amyotrophic lateral sclerosis.
✕Less likely to help
Patients with non-neurodegenerative conditions or those not affected by cellular transport issues may not benefit from this research.
What this research studies
This research investigates the mechanisms of bidirectional cargo transport in cells, focusing on the roles of molecular motors called kinesin and dynein. By examining how these motors work together and coordinate their actions, the research aims to uncover the underlying causes of transport deficiencies linked to neurodegenerative diseases such as Alzheimer's and ALS. The approach combines experimental techniques with computer modeling to analyze motor dynamics and their impact on cell function. Insights gained could lead to new therapeutic strategies for these conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for neurodegenerative diseases that affect millions of patients.
How similar studies have gone: Previous research has shown promising results in understanding motor dynamics in cellular transport, indicating that this approach has potential for significant advancements.
Where this research is happening
-
Pennsylvania State University, the
University Park, United States Active
Researchers
- Principal investigator: Noell, Crystal Renea — Pennsylvania State University, the
- Study coordinator: Noell, Crystal Renea
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.