Understanding how molecular motors help in chromosome separation during cell division
Mechanisms of microtubule motors and chromosome segregation
This study is looking at how tiny motors in our cells help make sure chromosomes are divided correctly during cell division, which is important for preventing problems like cancer, and it's designed for anyone interested in understanding how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Vermont & St Agric College NIH-funded |
| Lab location | 1 site (Burlington, United States) |
| Project ID | NIH-11010005 on NIH RePORTER |
What this research studies
This research investigates the role of molecular motors, specifically kinesins, in the accurate segregation of chromosomes during cell division. By examining how these motors function at a molecular level, the study aims to uncover the mechanisms that ensure chromosomes are properly organized and separated. The approach combines biophysics, live cell imaging, and structural mutagenesis to explore these processes across different biological scales, from individual molecules to entire organisms. This could provide insights into the errors that lead to conditions like cancer due to chromosome missegregation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cancers or congenital disorders related to chromosomal abnormalities.
Not a fit: Patients with conditions unrelated to chromosomal missegregation or those not affected by cancer or congenital disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for cancers and congenital disorders caused by chromosome missegregation.
How similar studies have performed: Other research has shown success in understanding molecular motors in cell division, indicating that this approach has a foundation in previously established findings.
Where this research is happening
Burlington, United States
- University of Vermont & St Agric College — Burlington, United States (Active)
Researchers
- Principal investigator: Stumpff, Jason K — University of Vermont & St Agric College
- Study coordinator: Stumpff, Jason K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.