Understanding how molecular machines spread genetic information in cells
Tracking how molecular machines propagate epigenetic information in time and space
This study is looking at how a special part of our DNA helps control which genes are turned on or off, and it's using new technology to see this process happening in real-time, which could help us understand diseases like cancer and improve treatments in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10906836 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which heterochromatin, a structure that represses gene activity, spreads across the genome to regulate which genes are active or inactive. By using advanced single-cell sensors, the team aims to observe this process in real-time and understand how it varies during cell development. The study focuses on the biochemical interactions that allow heterochromatin to adapt to different cellular environments, which could have implications for regenerative medicine and synthetic biology. Patients may benefit from insights gained into how gene regulation affects diseases, particularly cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to gene regulation, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to epigenetic mechanisms or gene regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression in diseases, potentially improving treatment options for patients.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Al-Sady, Bassem — University of California, San Francisco
- Study coordinator: Al-Sady, Bassem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.