Understanding how molecular machines manage gene activity over time and space
Tracking how molecular machines propagate epigenetic information in time and space
This study is looking at how a special part of our DNA, called heterochromatin, helps control which genes are turned on or off in our cells, and it aims to learn more about this process to better understand diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11169273 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which heterochromatin, a structure that represses gene activity, spreads across the genome to regulate which genes are active or inactive. By using advanced single-cell sensors, the team aims to observe and document how this process occurs in real-time, focusing on the biochemical interactions that enable heterochromatin to adapt during cell development. The findings could provide insights into how gene expression is controlled, which is crucial for understanding various diseases, including cancers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions influenced by gene regulation, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by epigenetic changes may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for manipulating gene expression, potentially improving treatments for diseases related to gene regulation.
How similar studies have performed: Previous research has shown promising results in understanding gene regulation through similar biochemical approaches, indicating potential for success in this area.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Al-Sady, Bassem — University of California, San Francisco
- Study coordinator: Al-Sady, Bassem
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.