Understanding how molecular machines maintain and repair DNA
Assembly and Dynamics of Molecular Machines in Genome Maintenance
['FUNDING_OTHER'] · UNIVERSITY OF IOWA · NIH-11062393
This study looks at how tiny machines in our cells fix DNA to keep us healthy and prevent diseases like cancer and neurodegenerative disorders, helping us understand how problems in this process can lead to age-related illnesses.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF IOWA (nih funded) |
| Locations | 1 site (IOWA CITY, UNITED STATES) |
| Trial ID | NIH-11062393 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms by which molecular machines repair DNA and maintain genome stability, which is crucial for preventing cancer and neurodegenerative diseases. It focuses on the roles of specific proteins involved in DNA repair processes and how their interactions and modifications influence their function. By studying these molecular dynamics, the research aims to uncover how disruptions in these processes can lead to diseases associated with aging and DNA damage. Patients may benefit from insights gained into how to better manage or treat conditions related to genome instability.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related neurodegenerative conditions or those at risk for such diseases.
Not a fit: Patients with non-age-related neurodegenerative disorders or those without any genetic predisposition to DNA repair issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing or treating age-related neurodegenerative diseases and cancer.
How similar studies have performed: Other research has shown success in understanding DNA repair mechanisms, indicating that this approach has a solid foundation in existing scientific knowledge.
Where this research is happening
IOWA CITY, UNITED STATES
- UNIVERSITY OF IOWA — IOWA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SPIES, MARIA — UNIVERSITY OF IOWA
- Study coordinator: SPIES, MARIA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: age associated neurodegenerative disease, age associated neurodegenerative disorder, age dependent neurodegenerative disease, age dependent neurodegenerative disorder, age-driven neurodegenerative disorders