Understanding how molecular machines help cells divide correctly
Biomechanics of molecular machines and multiscale non-linear systems
This study is looking at how tiny machines in our cells help make sure chromosomes are divided correctly during cell division, which is important for preventing issues like genetic disorders, and it's designed for anyone interested in understanding how our cells work.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11129640 on NIH RePORTER |
What this research studies
This research investigates the fundamental principles of molecular machines that enable cells to accurately segregate their chromosomes during cell division. By examining the interactions and forces involved in this process, the research aims to uncover how these mechanisms contribute to conditions like aneuploidy and genomic instability. The team employs innovative in vitro assays and advanced theoretical modeling to analyze the behavior of kinetochores and microtubules under various conditions, providing insights into the cellular processes that ensure proper chromosome division.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions related to aneuploidy or genomic instability, including certain cancers.
Not a fit: Patients with unrelated genetic disorders or those not affected by chromosome segregation issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for conditions related to chromosome segregation errors, such as cancer.
How similar studies have performed: Previous research has shown success in understanding molecular mechanisms of cell division, indicating that this approach has the potential for significant findings.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Grishchuk, Ekaterina L — University of Pennsylvania
- Study coordinator: Grishchuk, Ekaterina L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.