Understanding how molecular machines control gene expression and DNA repair
Advanced Computational Modeling of Molecular Machines in Gene Regulation and DNA Repair
This study is looking at how tiny machines in our cells help read and fix our genetic information, which is important for keeping our cells healthy and adapting to changes around us.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia State University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11044112 on NIH RePORTER |
What this research studies
This research investigates the intricate processes by which cells use molecular machines, specifically RNA polymerases, to transcribe genetic information and repair DNA. By employing advanced computational modeling alongside cryo-electron microscopy, the team aims to visualize and understand the structures and functions of these machines in various states. This approach could reveal critical insights into how gene regulation and DNA repair are interconnected, which is essential for maintaining cellular health and responding to environmental changes.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders related to gene regulation or DNA repair, such as Cockayne Syndrome or various cancer types.
Not a fit: Patients with conditions unrelated to gene regulation or DNA repair may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases linked to gene regulation and DNA repair deficiencies.
How similar studies have performed: Previous research has shown promise in using computational modeling to understand complex biological processes, indicating that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Georgia State University — Atlanta, United States (Active)
Researchers
- Principal investigator: Ivanov, Ivaylo Nikolaev — Georgia State University
- Study coordinator: Ivanov, Ivaylo Nikolaev
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.