Understanding how modified HDL contributes to heart disease
Official title: Unraveling the Role of Modified HDL in Atherogenesis
Funded at Medical College of Wisconsin · NIH-11065998 · Data updated 2026-11-12
This study is looking at how changes to a type of good cholesterol called HDL might affect heart health and the risk of heart disease, helping us learn more about how to prevent these issues for patients.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | December 5, 2024 |
| Project end | December 4, 2027 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 1F31HL178112-01 |
| Project ID | NIH-11065998 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for cardiovascular disease, particularly those with altered HDL levels or atherosclerosis.
✕Less likely to help
Patients who do not have cardiovascular risk factors or existing heart disease may not receive direct benefits from this research.
What this research studies
This research investigates the role of modified high-density lipoproteins (HDL) in the development of atherosclerosis, a major cause of cardiovascular disease. The study focuses on how oxidative modifications of HDL, caused by reactive aldehydes, affect its ability to transport cholesterol and protect against heart disease. By examining the mechanisms through which modified HDL influences cholesterol transport and macrophage behavior, the research aims to uncover new insights into cardiovascular health. Patients may benefit from a better understanding of HDL function and its implications for heart disease prevention.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing and treating cardiovascular disease by targeting HDL function rather than just cholesterol levels.
How similar studies have gone: Previous research has indicated that understanding HDL function can lead to significant advancements in cardiovascular disease treatment, suggesting this approach has potential for success.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Bobek, Jordan M — Medical College of Wisconsin
- Study coordinator: Bobek, Jordan M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.