Understanding how modifications to tRNA affect its function and production
Regulation of tRNA fragment biogenesis and function by nucleotide modifications
['FUNDING_R01'] · UNIV OF MASSACHUSETTS MED SCH WORCESTER · NIH-11067736
This study is looking at how tiny changes in tRNA, which helps make proteins in our cells, affect how these pieces are created and what they do, using yeast and stem cells to learn more about their role in health and disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF MASSACHUSETTS MED SCH WORCESTER (nih funded) |
| Locations | 1 site (WORCESTER, UNITED STATES) |
| Trial ID | NIH-11067736 on ClinicalTrials.gov |
What this research studies
This research investigates the role of nucleotide modifications in the biogenesis and function of tRNA fragments, which are crucial for protein translation. By studying both yeast and mammalian embryonic stem cells, the project aims to uncover how these modifications influence tRNA cleavage and the resulting fragments' roles in cellular processes. The researchers will utilize advanced techniques like deep sequencing to analyze various tRNA-modifying enzymes and their effects on tRNA biology. This work could provide insights into fundamental cellular mechanisms that may impact various diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions linked to tRNA dysfunction, such as specific cancers or metabolic disorders.
Not a fit: Patients with conditions unrelated to tRNA biology or those not experiencing any metabolic or genetic disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases related to tRNA dysfunction, including certain cancers and metabolic disorders.
How similar studies have performed: While the specific focus on tRNA modifications and fragments is relatively novel, similar approaches in understanding RNA biology have shown promising results in other contexts.
Where this research is happening
WORCESTER, UNITED STATES
- UNIV OF MASSACHUSETTS MED SCH WORCESTER — WORCESTER, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: RANDO, OLIVER J — UNIV OF MASSACHUSETTS MED SCH WORCESTER
- Study coordinator: RANDO, OLIVER J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.