Understanding how mobile genetic elements affect gene regulation in humans
Mobile element derived chromatin looping variability in human populations
This study is looking at how certain genetic changes in our DNA can affect our health and lead to diseases, and it aims to find better ways to understand these changes so that we can create more personalized treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10911287 on NIH RePORTER |
What this research studies
This research investigates the role of mobile element insertions (MEIs) in the human genome, which can lead to genetic variability and disease. By examining how these elements influence transcription factor binding and 3D chromatin looping, the study aims to develop new molecular and computational methods to better map MEIs across diverse human genomes. Patients may benefit from insights into how these genetic variations affect health and disease, potentially leading to more personalized medical approaches.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from diverse genetic backgrounds who may have experienced sporadic genetic diseases or variability.
Not a fit: Patients with well-defined genetic conditions that are not influenced by mobile element insertions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of genetic variability and its implications for human health, leading to improved diagnostic and therapeutic strategies.
How similar studies have performed: Previous research has shown promising results in understanding the impact of mobile elements on gene regulation, indicating that this approach has potential for significant findings.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Boyle, Alan P — University of Michigan at Ann Arbor
- Study coordinator: Boyle, Alan P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.