Understanding how mobile genetic elements affect animal development
Investigating the Molecular Basis of Transposon Regulation and Function in Animal Development
['FUNDING_OTHER'] · UNIVERSITY OF CALIFORNIA RIVERSIDE · NIH-11087652
This study is looking at tiny pieces of DNA that can move around and change how our genes work, especially during the early stages of development, to see how they can both help and hurt our genetic makeup, using fruit flies as a model to learn more about their effects on evolution and genetic differences.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA RIVERSIDE (nih funded) |
| Locations | 1 site (RIVERSIDE, UNITED STATES) |
| Trial ID | NIH-11087652 on ClinicalTrials.gov |
What this research studies
This research investigates transposable elements (TEs), which are mobile genetic components that can move within DNA and influence how genomes are organized and function. The study focuses on the mechanisms that regulate TEs, particularly their role in embryonic development and how they can both harm and benefit genetic integrity. By examining these elements in model organisms like Drosophila, the research aims to uncover the balance between TE activity and the silencing mechanisms that protect the genome. This could provide insights into the evolutionary significance of TEs and their impact on genetic variation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with genetic conditions linked to transposable elements or those interested in the genetic basis of developmental disorders.
Not a fit: Patients with conditions unrelated to genetic regulation or transposable elements may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic regulation and its implications for developmental biology and fertility.
How similar studies have performed: Previous research has shown that understanding transposable elements can lead to significant advancements in genetics and developmental biology, indicating that this approach has potential for success.
Where this research is happening
RIVERSIDE, UNITED STATES
- UNIVERSITY OF CALIFORNIA RIVERSIDE — RIVERSIDE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NINOVA, MARIA ANTONINOVA — UNIVERSITY OF CALIFORNIA RIVERSIDE
- Study coordinator: NINOVA, MARIA ANTONINOVA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.