Understanding how mobile DNA elements contribute to human cancers
Mobile element mutagenesis as a driver of human cancers
This research explores how certain mobile DNA pieces, called L1 elements, might cause or promote different types of cancer in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11159668 on NIH RePORTER |
What this research studies
Scientists are looking into how specific mobile DNA elements, known as L1 elements, become active in adult body tissues, including the brain and tumors. While these elements were once thought to be mostly silent in adults, recent findings suggest they can move around and insert themselves into our genes. This movement might disrupt important genes that normally protect us from cancer or activate genes that promote cancer growth. By understanding how these L1 elements work, we hope to learn more about how cancers start and develop.
Who could benefit from this research
Good fit: This foundational research focuses on understanding the biology of cancer at a genetic level and does not involve direct patient participation at this stage.
Not a fit: Patients seeking immediate treatment options or direct clinical intervention would not benefit from this basic science research.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify individuals at risk for certain cancers or develop new treatments that target these mobile DNA elements.
How similar studies have performed: Recent reports have shown L1 elements are active in some adult tissues and tumors, suggesting this approach builds on emerging evidence.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Devine, Scott E — University of Maryland Baltimore
- Study coordinator: Devine, Scott E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.