Understanding how mobile DNA elements affect brain disorders
Deep Learning Approaches to Decipher the Impact of Mobile Element Insertion on Alternative Splicing in Neurological Disorders
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-11088191
This study is looking at how certain pieces of DNA might affect brain health and contribute to conditions like Alzheimer's, using advanced technology to compare genetic information from healthy people and those with neurological disorders.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-11088191 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mobile element insertions (MEIs) in neurological disorders using advanced deep learning techniques. By analyzing genetic data from healthy individuals and patients with neurological disorders, the study aims to create a detailed map of how these DNA fragments influence brain function and contribute to diseases like Alzheimer's. The research will involve generating whole-genome sequencing data and examining transcriptional changes associated with these disorders. This innovative approach could lead to new insights into the genetic factors underlying neurological conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with neurological disorders such as Alzheimer's disease and their healthy counterparts for comparison.
Not a fit: Patients with neurological disorders not associated with mobile element insertions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of the genetic causes of neurological disorders and potentially lead to new therapeutic strategies.
How similar studies have performed: Other research has shown promise in using deep learning to analyze genetic data, suggesting that this approach could yield valuable insights into neurological disorders.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GAO, DADI — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: GAO, DADI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease