Understanding how MMP9 affects uterine contractions and birth timing
MMP9 Modulation of Uterine Contraction and Birth Timing
This study is looking at how a protein called MMP9 affects uterine contractions and whether blocking it could help keep the uterus calm to prevent early labor, which could be helpful for pregnant people at risk of preterm birth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project ID | NIH-11115892 on NIH RePORTER |
What this research studies
This research investigates the role of Matrix Metalloproteinase 9 (MMP9) in regulating uterine contractions, particularly focusing on how it may influence the timing of birth. The study aims to uncover the molecular mechanisms behind MMP9's effects and explore whether inhibiting MMP9 can help maintain uterine quiescence, potentially delaying preterm labor. Researchers will conduct experiments using both human uterine tissue and animal models to assess the impact of MMP9 on contractions and calcium signaling. The findings could lead to new therapeutic strategies to prevent preterm births.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals at risk of preterm labor or those with a history of preterm births.
Not a fit: Patients who are not pregnant or those with conditions unrelated to uterine contractions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent preterm births, improving outcomes for mothers and infants.
How similar studies have performed: Previous research has shown that targeting similar pathways in other contexts can be effective, suggesting potential for success in this area as well.
Where this research is happening
Reno, United States
- University of Nevada Reno — Reno, United States (Active)
Researchers
- Principal investigator: Burkin, Heather R — University of Nevada Reno
- Study coordinator: Burkin, Heather R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.