Understanding how MMP9 affects uterine contractions and birth timing
MMP9 Modulation of Uterine Contraction and Birth Timing
This study is looking at how a protein called MMP9 affects the contractions of the uterus, especially when it comes to preventing early labor, and it aims to find out if blocking MMP9 can help keep the uterus calm and reduce the chances of preterm birth.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project ID | NIH-10861061 on NIH RePORTER |
What this research studies
This research investigates the role of Matrix Metalloproteinase 9 (MMP9) in regulating uterine contractions, particularly in the context of preterm birth. The study aims to uncover the molecular mechanisms by which MMP9 influences these contractions and whether inhibiting MMP9 can help maintain uterine quiescence, potentially delaying premature labor. Researchers will conduct experiments using both human uterine tissue and animal models to assess the effects of MMP9 on contraction and the potential for targeted therapies to reduce preterm births.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals at risk of preterm labor or those with a history of preterm births.
Not a fit: Patients who are not pregnant or those who have no history of preterm labor may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help prevent preterm births, improving outcomes for mothers and infants.
How similar studies have performed: While the specific approach of targeting MMP9 is novel, similar research has shown promise in understanding the regulation of uterine contractions and preventing preterm labor.
Where this research is happening
Reno, United States
- University of Nevada Reno — Reno, United States (Active)
Researchers
- Principal investigator: Burkin, Heather R — University of Nevada Reno
- Study coordinator: Burkin, Heather R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.