Understanding how MLLT3 proteins affect blood stem cells
REGULATION OF HUMAN HEMATOPOIETIC STEM CELL FATE VIA MLLT3 ISOFORMS
This study is looking at a protein called MLLT3 to see how it helps blood stem cells from umbilical cord blood grow and stay healthy, which could lead to better treatments for blood-related conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11002289 on NIH RePORTER |
What this research studies
This research investigates the role of MLLT3 proteins in regulating human hematopoietic stem cells (HSCs), which are crucial for blood cell production. The study focuses on how maintaining MLLT3 levels in cultured cord blood HSCs can lead to their expansion without causing them to transform into cancerous cells. By examining different isoforms of MLLT3, the research aims to uncover their distinct functions and how they influence HSC self-renewal and differentiation. This could provide insights into improving blood stem cell therapies and transplantation outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with blood disorders who may benefit from improved blood stem cell therapies or transplantation.
Not a fit: Patients with conditions unrelated to blood disorders or those who do not require blood stem cell treatments may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance the effectiveness of blood stem cell therapies, leading to better treatment options for patients with blood disorders.
How similar studies have performed: Previous research has shown promising results in manipulating stem cell factors for therapeutic purposes, indicating potential success for this approach.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Mikkola, Hanna Katri Annikki — University of California Los Angeles
- Study coordinator: Mikkola, Hanna Katri Annikki
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.