Understanding how Mll4 affects the development of the palate in babies
Epigenetic regulatory roles of Mll4 in palate development
This study is looking at how a specific gene called Mll4 helps form the roof of the mouth in babies, which is important for preventing cleft palate, and it aims to find ways to improve diagnosis and treatment for this condition.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University of New York at Buffalo NIH-funded |
| Lab location | 1 site (Amherst, United States) |
| Project ID | NIH-10459544 on NIH RePORTER |
What this research studies
This research investigates the role of the Mll4 gene in the development of the palate, which is crucial for preventing cleft palate in newborns. By studying mice with specific genetic modifications, the researchers aim to uncover the molecular pathways that lead to palate formation and how disruptions can cause conditions like cleft palate. The approach involves examining gene expression and cellular behaviors during embryonic development to identify potential targets for improved diagnosis and treatment. This research could ultimately lead to better prevention strategies for cleft palate and related craniofacial abnormalities.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns and children up to 11 years old who are at risk for or have been diagnosed with cleft palate.
Not a fit: Patients who are adults or do not have any craniofacial abnormalities related to cleft palate may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for diagnosing and preventing cleft palate in newborns.
How similar studies have performed: Previous research has shown success in understanding genetic factors in craniofacial development, making this approach promising but still requiring further exploration.
Where this research is happening
Amherst, United States
- State University of New York at Buffalo — Amherst, United States (Active)
Researchers
- Principal investigator: Kwon, Hyuk Jae Edward — State University of New York at Buffalo
- Study coordinator: Kwon, Hyuk Jae Edward
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.