Understanding how mitochondrial structure affects cell function and disease
Probing structural and biophysical mechanisms of mitochondrial membrane ultrastructure
['FUNDING_OTHER'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10876478
This study is looking at the tiny powerhouses in our cells called mitochondria to understand how their shape and function might be connected to diseases like cancer and neurological disorders, with the hope that this knowledge can help develop new treatments for patients.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10876478 on ClinicalTrials.gov |
What this research studies
This research investigates the intricate structure of mitochondria, which are essential for energy production in cells. By using advanced imaging techniques like cryo-electron microscopy, the team aims to uncover how changes in mitochondrial shape and function are linked to various diseases, including neurological disorders and cancer. Patients may benefit from insights gained about how mitochondrial abnormalities contribute to their conditions, potentially leading to new therapeutic strategies. The research will also explore how proteins interact within mitochondria to regulate their structure and function.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with neurological disorders, cardiac conditions, or cancers that may be related to mitochondrial abnormalities.
Not a fit: Patients with conditions unrelated to mitochondrial function or structure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for diseases linked to mitochondrial dysfunction.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function through advanced imaging techniques, indicating that this approach has potential for success.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHAO, LUKE H. — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: CHAO, LUKE H.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers