Understanding how mitochondrial stress affects liver health
Mitochondrial stress in liver function and dysfunction
['FUNDING_OTHER'] · AUGUSTA UNIVERSITY · NIH-10909565
This study is looking at how tiny powerhouses in your liver cells, called mitochondria, handle stress and stay healthy, especially focusing on a protein called OPA1, to help us learn more about how the liver can keep working well even when things go wrong, which could help us understand liver diseases better.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | AUGUSTA UNIVERSITY (nih funded) |
| Locations | 1 site (AUGUSTA, UNITED STATES) |
| Trial ID | NIH-10909565 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondria in liver function and how they respond to stress. It focuses on a specific protein, OPA1, which is crucial for mitochondrial health. By studying mice with a genetic modification that affects OPA1, researchers aim to uncover how the liver maintains its function despite mitochondrial dysfunction. The goal is to understand the integrated stress response that helps the liver cope with challenges, which could lead to new insights into liver diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with liver conditions or those at risk for liver diseases.
Not a fit: Patients with non-liver related health issues may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preserving liver health and treating liver diseases.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial function in various organs, making this approach both relevant and potentially impactful.
Where this research is happening
AUGUSTA, UNITED STATES
- AUGUSTA UNIVERSITY — AUGUSTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CHEN, WEIQIN — AUGUSTA UNIVERSITY
- Study coordinator: CHEN, WEIQIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.