Understanding how mitochondrial stress affects liver aging and cancer progression
Project 1: The role of mitochondrial stress in liver aging and cancer progression and intervention via oxidative mitohormesis
['FUNDING_P01'] · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · NIH-10908395
This study is looking at how problems with tiny parts of our cells and stress from oxygen can affect aging and the risk of cancer, especially in the liver, to find new ways to keep our liver healthy and prevent cancer as we get older.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE (nih funded) |
| Locations | 1 site (LA JOLLA, UNITED STATES) |
| Trial ID | NIH-10908395 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial dysfunction and oxidative stress in the aging process and its connection to cancer development. By examining how these cellular processes interact, the study aims to uncover mechanisms that contribute to age-related liver dysfunction and cancer susceptibility. The researchers will explore a novel signaling pathway known as oxidative mitohormesis, which may help protect against these age-related issues. Patients may benefit from insights that could lead to new interventions for liver health and cancer prevention.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over the age of 21 who are experiencing age-related health issues or are at risk for liver dysfunction and cancer.
Not a fit: Patients under the age of 21 or those with unrelated health conditions may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing liver dysfunction and reducing cancer risk in aging individuals.
How similar studies have performed: Other research has shown promising results in understanding mitochondrial dynamics and their impact on aging and cancer, suggesting that this approach could yield significant insights.
Where this research is happening
LA JOLLA, UNITED STATES
- SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE — LA JOLLA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHADEL, GERALD — SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
- Study coordinator: SHADEL, GERALD
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.