Understanding how mitochondrial proteins regulate energy production
Official title: Upstream Requirements for the Regulation of Mitochondrial Bioenergetics by the Mitochondrial Acyl Carrier Protein
Funded at Van Andel Research Institute · NIH-11089338 · Data updated 2026-11-12
This study is looking at how a special protein in our cells helps manage energy production in the mitochondria, which are like tiny power plants, and it hopes to find new ways to treat diseases like cancer and heart failure that are caused by problems in these power plants.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $48,538 |
| NIH project number | 5F30GM154476-02 |
| Project ID | NIH-11089338 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals suffering from mitochondrial diseases or metabolic disorders related to mitochondrial dysfunction.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or those who do not have metabolic disorders may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial acyl carrier protein (mtACP) in regulating energy production within mitochondria, which are crucial for cellular metabolism. By exploring how mtACP is modified and functions in energy metabolism, the research aims to uncover new therapeutic strategies for diseases linked to mitochondrial dysfunction, such as cancer and heart failure. The approach involves studying the biochemical processes that govern mtACP's role in energy production and its interactions with other mitochondrial components.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients with mitochondrial diseases and other metabolic disorders.
How similar studies have gone: Previous research has shown promising results in targeting mitochondrial function for therapeutic purposes, indicating that this approach has potential for success.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Wedan, Riley — Van Andel Research Institute
- Study coordinator: Wedan, Riley
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.