Understanding how mitochondrial proteins function in diseases
Systems-to-structure approaches for defining mitochondrial protein function
This study is looking at tiny parts of our cells called mitochondria that help produce energy, to better understand how certain proteins in them work, especially in relation to diseases like Alzheimer's, Parkinson's, and diabetes, with the hope of finding new ways to help diagnose and treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11074631 on NIH RePORTER |
What this research studies
This research focuses on the critical roles of mitochondria, the energy-producing structures in cells, and aims to uncover the functions of mitochondrial proteins that are not well understood. By identifying these proteins and their roles in diseases like Alzheimer's, Parkinson's, and diabetes, the research seeks to improve our ability to diagnose and treat mitochondrial dysfunction. The approach involves innovative techniques to systematically explore the biochemical functions of these proteins, which could lead to new therapeutic strategies. Patients may benefit from advancements in understanding and treating conditions linked to mitochondrial dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with mitochondrial diseases or conditions such as Alzheimer's, Parkinson's, and type 2 diabetes.
Not a fit: Patients with conditions unrelated to mitochondrial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic options for patients with mitochondrial-related diseases.
How similar studies have performed: Previous research has shown promise in understanding mitochondrial functions, but this approach aims to fill significant gaps in knowledge, making it a novel endeavor.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Pagliarini, David J — Washington University
- Study coordinator: Pagliarini, David J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.