Understanding how mitochondrial proteins control heme production
Regulation of heme synthesis by mitochondrial proteins
This study is looking at how certain proteins help manage heme, a vital part of our cells, in the mitochondria, which are the powerhouses of our cells, to better understand and improve health for people with conditions related to heme and iron metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10739151 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate heme metabolism in mitochondria, which is crucial for various life-sustaining processes, including respiration. The focus is on identifying specific proteins that facilitate the transport of heme and porphyrins within mitochondria, as well as those involved in maintaining mitochondrial homeostasis. By exploring these regulatory mechanisms, the research aims to shed light on disorders related to heme synthesis and iron metabolism, particularly in non-erythroid cells. Patients may benefit from insights gained into how these processes can be better regulated to improve health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research include children and young individuals with iron metabolism disorders or related conditions affecting heme synthesis.
Not a fit: Patients with conditions unrelated to heme metabolism or mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment of disorders related to heme synthesis and iron metabolism.
How similar studies have performed: While the focus on mitochondrial heme synthesis in non-erythroid cells is relatively novel, previous studies have shown success in understanding heme regulation in erythroid cells.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Yien, Yvette Y — University of Pittsburgh at Pittsburgh
- Study coordinator: Yien, Yvette Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.