Understanding how mitochondrial proteins control heme production
Regulation of heme synthesis by mitochondrial proteins
This study is looking at how certain proteins in our cells help make heme, an important part of our body's breathing process, and it aims to understand how these proteins can affect children's health, especially in conditions related to iron and heme production.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10664950 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which mitochondrial proteins regulate the production of heme, a crucial component for various biological processes, including respiration. The project focuses on identifying specific proteins that facilitate the transport of heme and those involved in maintaining mitochondrial health. By exploring these regulatory mechanisms, the research aims to shed light on disorders related to heme synthesis and iron metabolism, which can affect children's health. The approach combines molecular biology techniques with studies on different cell types to gain a comprehensive understanding of heme regulation.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-21 who are experiencing disorders related to heme synthesis or iron metabolism.
Not a fit: Patients who do not have any disorders related to heme synthesis or iron metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for disorders related to heme synthesis and iron metabolism, particularly in children.
How similar studies have performed: Previous research has shown success in understanding heme synthesis in erythroid cells, but this project aims to expand that knowledge to other cell types, making it a novel approach.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Yien, Yvette Y — University of Pittsburgh at Pittsburgh
- Study coordinator: Yien, Yvette Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.