Understanding how mitochondrial proteins are managed in heart diseases caused by Complex I dysfunction
Official title: A novel mechanism of mitochondrial protein turnover in Complex I deficient mitochondrial cardiomyopathy
Funded at University of Utah · NIH-10912004 · Data updated 2026-11-12
This study is looking at how tiny parts of our cells called mitochondria produce substances that can harm the heart when they don't work properly, especially in heart diseases linked to a specific problem in energy production, and it's aimed at finding new ways to help improve treatments for these conditions.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | September 30, 2022 |
| Project end | September 29, 2027 |
| Funding year | 2024 |
| Award (this year) | $39,447 |
| NIH project number | 5F30HL165806-03 |
| Project ID | NIH-10912004 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with mitochondrial cardiomyopathies or related cardiac diseases, particularly those with Complex I dysfunction.
✕Less likely to help
Patients with cardiac conditions unrelated to mitochondrial dysfunction may not benefit from this research.
What this research studies
This research investigates the role of mitochondria in producing reactive oxygen species (ROS) and how this affects heart diseases, particularly those related to Complex I dysfunction. By studying a mouse model, the researchers aim to uncover mechanisms that help maintain energy production in cells when Complex I is impaired. They focus on a protein called the mitochondrial calcium uniporter (MCU) and its interactions with Complex I, exploring how these interactions change under dysfunctional conditions. The goal is to identify new ways to regulate mitochondrial proteins that could lead to better treatments for related diseases.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating mitochondrial cardiomyopathies and other related conditions.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction and its implications in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Cvrti, Sandra Hyunjoo — University of Utah
- Study coordinator: Cvrti, Sandra Hyunjoo
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.