Understanding how mitochondrial NADPH and NADK2 support cell growth and division
Revealing the essential functions of mitochondrial NADPH and NADK2 for cell growth and proliferation
This study is looking at how certain molecules and enzymes help our cells grow and stay healthy, especially when they’re dividing quickly, which can sometimes cause problems; understanding this could help people with neurological and developmental disorders find better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-10916307 on NIH RePORTER |
What this research studies
This research investigates the essential roles of mitochondrial NADPH and the enzyme NADK2 in supporting cell growth and proliferation. It focuses on how these components help maintain a balance in cellular metabolism, particularly during periods of rapid cell division when reactive oxygen species can be harmful. By studying the mechanisms that regulate NADPH production and the impact of NADK2 mutations, the research aims to uncover important insights that could relate to various neurological and developmental disorders. Patients may benefit from a better understanding of these processes, which could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with mutations in NADK2 or those affected by neurological and developmental disorders linked to cellular metabolism.
Not a fit: Patients with conditions unrelated to mitochondrial function or cellular metabolism may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for conditions related to cell growth and proliferation, including certain cancers and neurological disorders.
How similar studies have performed: Previous research has shown promising results in understanding the roles of NADPH and NADK in cellular processes, suggesting that this approach could yield valuable insights.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Hoxhaj, Gerta N/a — Ut Southwestern Medical Center
- Study coordinator: Hoxhaj, Gerta N/a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.