Understanding how mitochondrial mutations affect aging
Temporal control of mitochondrial mutagenesis
['FUNDING_R01'] · UNIVERSITY OF SOUTHERN CALIFORNIA · NIH-10890670
This study is looking at how changes in tiny parts of our cells, called mitochondrial DNA, might affect aging and diseases like cancer and brain disorders, using special mice to see when these changes start to cause problems, which could help us find better ways to treat these issues in the future.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF SOUTHERN CALIFORNIA (nih funded) |
| Locations | 1 site (Los Angeles, UNITED STATES) |
| Trial ID | NIH-10890670 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial DNA mutations in the aging process and age-related diseases. By using a specialized mouse model, researchers can control when these mutations occur and observe their effects over time. The goal is to identify when these mutations begin to contribute to diseases like cancer and neurodegeneration, which could lead to better timing for potential treatments aimed at preventing these conditions. Patients may benefit from insights that could inform future therapies targeting aging.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals experiencing age-related health issues or those with a family history of mitochondrial diseases.
Not a fit: Patients with acute conditions unrelated to aging or mitochondrial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing age-related diseases by targeting mitochondrial mutations early in life.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial mutations and their role in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, UNITED STATES
- UNIVERSITY OF SOUTHERN CALIFORNIA — Los Angeles, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: VERMULST, MARC — UNIVERSITY OF SOUTHERN CALIFORNIA
- Study coordinator: VERMULST, MARC
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.