Understanding how mitochondrial metabolism affects lung inflammation caused by bacteria.
The Role of Mitochondrial Metabolism in Neutrophilic Lung Inflammation
This study is looking at how a type of immune cell called neutrophils helps fight lung infections by using energy from fats, and it hopes to find new ways to help people with bacterial pneumonia and similar lung issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10837032 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils, a type of immune cell, in fighting bacterial infections in the lungs. It focuses on how these cells use mitochondrial metabolism, particularly fatty acids, to generate energy necessary for their functions. By using animal models, the study aims to uncover how disruptions in this metabolic process can lead to increased susceptibility to infections. Patients may benefit from insights that could lead to new treatments for bacterial pneumonia and related lung conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of bacterial pneumonia or those at high risk for lung infections.
Not a fit: Patients with non-bacterial lung infections or those without a history of lung inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for improving immune responses in patients with bacterial pneumonia.
How similar studies have performed: Other research has shown promising results in understanding immune cell metabolism, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Noto, Michael James — University of Maryland Baltimore
- Study coordinator: Noto, Michael James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.