Understanding how mitochondrial metabolism affects liver cancer
Official title: Deciphering the role of mitochondrial metabolism in liver cancer
Funded at Rockefeller University · NIH-11012263 · Data updated 2026-11-12
This study is looking at how changes in cell energy production might affect liver cancer and how well different treatments work, with the goal of finding better, more personalized options for patients like you.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 1, 2024 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $142,066 |
| NIH project number | 5K99CA286722-02 |
| Project ID | NIH-11012263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with liver cancer who have specific oncogenic alterations.
✕Less likely to help
Patients with liver cancer who do not have identifiable oncogenic mutations may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial metabolism in liver cancer, focusing on how specific genetic mutations influence tumor metabolism and treatment responses. By using advanced techniques to analyze mitochondrial metabolites in cancer cells, the study aims to identify which tumors may benefit from metabolism-based therapies. This approach seeks to provide a more personalized treatment strategy for liver cancer patients, addressing the limitations of current therapies.
Why it matters
Potential benefit: If successful, this research could lead to more effective, tailored therapies for liver cancer patients based on their unique tumor metabolism.
How similar studies have gone: While metabolism-focused therapies are gaining interest, this specific approach using mitochondrial profiling in liver cancer is relatively novel and has not been extensively tested.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Unlu, Gokhan — Rockefeller University
- Study coordinator: Unlu, Gokhan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.