Understanding how mitochondrial inheritance affects outcomes in blood disorders after stem-cell transplants
Prognostic implications of mitochondrial inheritance in myelodysplastic syndromes after stem-cell transplantation
This study is looking at how the DNA from your mitochondria might help doctors better understand and predict outcomes for patients with myelodysplastic syndromes who have had stem-cell transplants, so they can provide more personalized and effective care.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project ID | NIH-11061782 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial DNA in patients with myelodysplastic syndromes (MDS) who have undergone stem-cell transplantation. It aims to identify genetic and epigenetic markers that could predict patient outcomes more accurately than current models, which primarily focus on non-genetic factors. By analyzing mitochondrial inheritance patterns, the study seeks to improve prognostic assessments and tailor treatment approaches for better patient care. The research will utilize advanced omics technologies to gather and analyze data related to mitochondrial function and its impact on hematopoietic health.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with myelodysplastic syndromes who are considering or have undergone allogeneic hematopoietic stem-cell transplantation.
Not a fit: Patients with MDS who are not candidates for stem-cell transplantation or those with other unrelated blood disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment strategies for patients with MDS, potentially improving survival rates and quality of life after stem-cell transplantation.
How similar studies have performed: Previous research has shown that genetic factors, including mitochondrial DNA variations, can influence treatment outcomes in hematologic diseases, suggesting that this approach has potential for success.
Where this research is happening
Milwaukee, United States
- Medical College of Wisconsin — Milwaukee, United States (Active)
Researchers
- Principal investigator: Dong, Jing — Medical College of Wisconsin
- Study coordinator: Dong, Jing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.