Understanding how mitochondrial health affects Inflammatory Bowel Disease
Mitonuclear Communication During the Pathogenesis of Inflammatory Bowel Disease
This study is looking at how problems with tiny energy factories in our cells, called mitochondria, might lead to Inflammatory Bowel Disease (IBD), and it aims to find new ways to help improve treatment for people living with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10754860 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial dysfunction in the development of Inflammatory Bowel Disease (IBD), a condition affecting millions of Americans. The team will study how the health of mitochondria in the intestinal lining contributes to IBD and explore potential therapies aimed at restoring mitochondrial function. By examining protein levels and gene expression related to mitochondrial health, the researchers aim to identify new treatment strategies that could improve patient outcomes. The study includes both laboratory experiments and analysis of patient samples to gather comprehensive data.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Inflammatory Bowel Disease, including conditions like ulcerative colitis.
Not a fit: Patients without a diagnosis of Inflammatory Bowel Disease or those with unrelated gastrointestinal disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve the management and treatment of Inflammatory Bowel Disease.
How similar studies have performed: Previous research has shown promising results in targeting mitochondrial dysfunction as a therapeutic approach in various inflammatory conditions, suggesting potential for success in this area.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Mollen, Kevin P — University of Pittsburgh at Pittsburgh
- Study coordinator: Mollen, Kevin P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.