Understanding how mitochondrial health affects immune responses
Mechanistic link between mitochondrial cristae integrity and Th1 responses
This study is looking at how certain genes might affect the immune system, especially T cells, to better understand autoimmune diseases, and it could help patients learn more about their conditions and find new treatment options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-11044360 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that influence the immune system's tendency towards autoimmunity, particularly focusing on T cells. Using a hybrid mouse model, the study aims to identify specific genetic variations that affect T cell function and their response to autoimmune conditions. By examining the role of a gene called TMEM11, which is linked to mitochondrial structure and function, the research seeks to uncover how these cellular mechanisms contribute to autoimmune diseases. Patients may benefit from insights gained about the genetic basis of their conditions and potential new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those with a family history of autoimmune diseases.
Not a fit: Patients with non-autoimmune conditions or those without a genetic predisposition to autoimmunity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating autoimmune diseases by targeting mitochondrial health.
How similar studies have performed: Previous research has shown promising results in understanding the genetic basis of autoimmunity, suggesting that this approach could yield valuable insights.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Gwack, Yousang — University of California Los Angeles
- Study coordinator: Gwack, Yousang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.