Understanding how mitochondrial health affects bone strength and disease
Role of Mitochondrial Quality Control in Bone Homeostasis and Disease
['FUNDING_R01'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-10906229
This study is looking at how a protein called Sirtuin-3 helps keep our bones healthy as we age and deal with lower estrogen levels, which can lead to osteoporosis, and it's aimed at finding new ways to help older adults maintain their bone strength.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-10906229 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial quality control in bone health, particularly focusing on how aging and estrogen deficiency contribute to osteoporosis. The study examines the function of a protein called Sirtuin-3 (Sirt3), which is crucial for maintaining healthy mitochondria in bone cells. By using animal models, the researchers aim to uncover the mechanisms by which Sirt3 influences bone mass and resorption, potentially leading to new therapeutic strategies for osteoporosis in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who are at risk for osteoporosis due to aging or estrogen deficiency.
Not a fit: Patients who are younger than 65 or those without risk factors for osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that help maintain bone density and prevent osteoporosis in older adults.
How similar studies have performed: Previous studies have shown conflicting results regarding the role of Sirt3 in bone health, indicating that this research could provide novel insights into an important area of osteoporosis research.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, HA-NEUI — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: KIM, HA-NEUI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.