Understanding how mitochondrial glutathione affects cancer growth and spread
Official title: Dissecting the role of mitochondrial glutathione homeostasis in cancer
Funded at Rockefeller University · NIH-11132572 · Data updated 2026-11-12
This study is looking at how cancer cells use nutrients to grow and survive, especially focusing on a key antioxidant called mitochondrial glutathione, which helps them cope with stress when spreading in the body; the goal is to find new ways to target cancer metabolism for better treatments.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 14, 2023 |
| Project end | September 13, 2025 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 5F99CA284249-02 |
| Project ID | NIH-11132572 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with various types of cancer, particularly those experiencing metastasis.
✕Less likely to help
Patients with non-cancerous conditions or those whose cancer is not metastatic may not benefit from this research.
What this research studies
This research investigates how cancer cells sense and utilize nutrients, focusing on the role of mitochondrial glutathione, a crucial antioxidant. By using advanced techniques like CRISPR screens, the study aims to uncover how this molecule helps cancer cells adapt to metabolic stresses during metastasis. The research will explore the dynamics of glutathione transport within cells, particularly its regulation and impact on cancer progression. This could lead to new insights into how to target cancer metabolism for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target cancer metabolism, potentially improving treatment outcomes for patients with cancer.
How similar studies have gone: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting that this approach could yield significant insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Liu, Yuyang — Rockefeller University
- Study coordinator: Liu, Yuyang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.