Understanding how mitochondrial function affects intestinal stem cells
Official title: Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells
Funded at Univ of North Carolina Chapel Hill · NIH-11137976 · Data updated 2026-11-12
This study is looking at how the energy-making parts of cells, called mitochondria, affect the health of intestinal stem cells and their connection to inflammatory bowel disease (IBD), using both human cells and mice to better understand how problems with these mitochondria might cause inflammation and issues in the intestines.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $115,288 |
| NIH project number | 1K01DK140610-01A1 |
| Project ID | NIH-11137976 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with inflammatory bowel disease or those experiencing related gastrointestinal issues.
✕Less likely to help
Patients without gastrointestinal conditions or those who do not have a history of inflammatory bowel disease may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial metabolism in human intestinal stem cells (ISCs) and how it relates to inflammatory bowel disease (IBD). By utilizing advanced techniques such as genetic engineering and metabolic studies, the research aims to uncover the mechanisms that regulate mitochondrial function and its impact on ISC activity. The study will involve both laboratory experiments with human cells and in vivo studies using mouse models to explore how mitochondrial dysfunction can lead to inflammation and abnormal cell behavior in the intestines.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating inflammatory bowel disease and improving intestinal health.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial function in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Burclaff, Joseph R — Univ of North Carolina Chapel Hill
- Study coordinator: Burclaff, Joseph R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.