Understanding how mitochondrial function affects intestinal stem cells
Transcriptional regulation of mitochondrial metabolism in human intestinal stem cells
This study is looking at how the energy-making parts of cells, called mitochondria, affect the health of intestinal stem cells and their connection to inflammatory bowel disease (IBD), using both human cells and mice to better understand how problems with these mitochondria might cause inflammation and issues in the intestines.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11137976 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial metabolism in human intestinal stem cells (ISCs) and how it relates to inflammatory bowel disease (IBD). By utilizing advanced techniques such as genetic engineering and metabolic studies, the research aims to uncover the mechanisms that regulate mitochondrial function and its impact on ISC activity. The study will involve both laboratory experiments with human cells and in vivo studies using mouse models to explore how mitochondrial dysfunction can lead to inflammation and abnormal cell behavior in the intestines.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with inflammatory bowel disease or those experiencing related gastrointestinal issues.
Not a fit: Patients without gastrointestinal conditions or those who do not have a history of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for treating inflammatory bowel disease and improving intestinal health.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in other contexts, suggesting potential for success in this novel approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Burclaff, Joseph R — Univ of North Carolina Chapel Hill
- Study coordinator: Burclaff, Joseph R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.