Understanding how mitochondrial function affects heart cell death during heart attacks
Molecular Regulation of Mitochondrial Permeability Transition and its Role in Regulated Necrosis
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-10869937
This study is looking at how certain heart cells die during a heart attack and is specifically focusing on a part of the cell called the mitochondrial permeability transition pore (MPTP), with the hope that understanding this better could help develop new treatments to protect heart cells when blood flow is blocked.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-10869937 on ClinicalTrials.gov |
What this research studies
This research investigates the mechanisms behind regulated necrosis in heart cells, particularly focusing on the mitochondrial permeability transition pore (MPTP) and its role in cell death during heart attacks. By studying genetically modified mice, the researchers aim to identify the components that regulate the MPTP and how they contribute to mitochondrial dysfunction and cell death. The approach involves examining the effects of calcium levels and specific inhibitors on the MPTP to better understand its regulation. This knowledge could lead to new therapeutic strategies to protect heart cells during ischemic events.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at high risk for myocardial infarction or those with existing heart conditions.
Not a fit: Patients with non-cardiac conditions or those who have already experienced irreversible heart damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent heart cell death during heart attacks, potentially improving survival rates and heart function.
How similar studies have performed: Previous research has shown promise in understanding mitochondrial function and its implications for heart disease, suggesting that this approach could yield valuable insights.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KARCH, JASON MICHAEL — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: KARCH, JASON MICHAEL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.