Understanding how mitochondrial dysfunction affects brain metabolism
Investigating Citric Acid Cycle Perturbations in Complex I Deficient Mitochondrial Encephalopathy
This study looks at how certain brain changes from mitochondrial diseases, especially those affecting energy production, can impact brain health, and it hopes to find new ways to help people with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project ID | NIH-11093415 on NIH RePORTER |
What this research studies
This research investigates the metabolic changes in the brain caused by mitochondrial diseases, particularly focusing on Complex I deficiency. It aims to understand how disruptions in the citric acid cycle contribute to neuronal decline and the production of energy in brain cells. By studying a specific mouse model, researchers will explore the biochemical pathways involved and how they may lead to potential therapeutic targets. Patients with mitochondrial encephalopathies may find insights into their condition through this research.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mitochondrial encephalopathies, particularly those with Complex I deficiencies.
Not a fit: Patients with mitochondrial diseases not related to Complex I deficiencies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for patients suffering from mitochondrial diseases.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction, but this specific approach to studying the citric acid cycle in relation to Complex I deficiency is relatively novel.
Where this research is happening
Columbia, United States
- University of South Carolina at Columbia — Columbia, United States (Active)
Researchers
- Principal investigator: Frizzell, Norma — University of South Carolina at Columbia
- Study coordinator: Frizzell, Norma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.