Understanding how mitochondrial DNA levels change with aging
Official title: Elucidating mechanisms of mitochondrial DNA copy number regulation in aging
Funded at Vanderbilt University · NIH-11162914 · Data updated 2026-11-12
This study is looking at how the amount of mitochondrial DNA changes as we get older, and it hopes to find ways to boost these levels to help improve health and fight age-related diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | May 1, 2025 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $34,295 |
| NIH project number | 1F30AG089936-01A1 |
| Project ID | NIH-11162914 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or those interested in interventions that may improve their health as they age.
✕Less likely to help
Patients who are not experiencing age-related diseases or are under the age of 21 may not benefit from this research.
What this research studies
This research investigates the mechanisms that regulate mitochondrial DNA (mtDNA) copy number as people age. By studying the relationship between mtDNA levels and aging, the research aims to identify potential therapeutic strategies to combat age-related diseases. The approach includes examining cellular and molecular processes in model organisms, such as C. elegans, to understand how mtDNA levels decline with age and how this impacts overall health. The ultimate goal is to develop interventions that can enhance mtDNA levels and improve mitochondrial function in aging individuals.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that delay or prevent age-related diseases by targeting mitochondrial dysfunction.
How similar studies have gone: Other research has shown promising results in targeting mitochondrial dysfunction, suggesting that this approach could be effective in addressing age-related health challenges.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Garcia, Arlene — Vanderbilt University
- Study coordinator: Garcia, Arlene
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.