Understanding how mitochondrial DNA is maintained in cells
Systems analysis of mitochondrial genome maintenance in physiological context
This study is looking at how our cells manage their energy by understanding the tiny parts of DNA found in mitochondria, which are important for cell health, and it could help us learn more about diseases related to this DNA and how they are passed down in families.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Berkeley NIH-funded |
| Lab location | 1 site (Berkeley, United States) |
| Project ID | NIH-10908559 on NIH RePORTER |
What this research studies
This research investigates the mechanisms that regulate the synthesis and segregation of mitochondrial DNA (mtDNA) in animal cells. By identifying the protein components involved in mtDNA nucleoid complexes, the study aims to understand how mtDNA is maintained and how it affects cellular function. The research employs advanced techniques such as live-cell microscopy, proteomics, and single-cell transcriptional analyses to explore these processes. Insights gained could lead to better understanding of mtDNA-related diseases and their inheritance.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with mitochondrial diseases or those at risk of inheriting such conditions.
Not a fit: Patients with conditions unrelated to mitochondrial function or those who do not have a family history of mitochondrial diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating mitochondrial diseases and improving cellular health.
How similar studies have performed: Other research has shown promise in understanding mitochondrial function and its implications for disease, suggesting that this approach could yield valuable insights.
Where this research is happening
Berkeley, United States
- University of California Berkeley — Berkeley, United States (Active)
Researchers
- Principal investigator: Lewis, Samantha C — University of California Berkeley
- Study coordinator: Lewis, Samantha C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.