Understanding how mitochondrial DNA is maintained and eliminated
Official title: The mechanism of elimination of the mitochondrial DNA replisome
Funded at University of North Florida · NIH-10880042 · Data updated 2026-11-12
This study is looking into how our cells get rid of faulty parts of their energy-producing machinery, which could help us find better ways to understand and treat diseases linked to problems with our mitochondria, the tiny powerhouses in our cells.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of North Florida NIH-funded |
| Lab location | 1 site (Jacksonville, United States) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2021 |
| Award (this year) | $210,164 |
| NIH project number | 7R15GM139104-02 |
| Project ID | NIH-10880042 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with mitochondrial DNA disorders or those at risk for such conditions.
✕Less likely to help
Patients with non-mitochondrial related health issues may not receive any benefit from this research.
What this research studies
This research investigates the mechanisms behind the elimination of the mitochondrial DNA replisome, which is crucial for maintaining mitochondrial function. Mitochondria are responsible for producing energy in our cells, and defects in their DNA can lead to serious health issues, including degenerative diseases affecting the heart, muscles, and brain. By exploring how large-scale deletions in mitochondrial DNA occur, the research aims to uncover potential pathways that could lead to better understanding and treatment of mitochondrial-related disorders.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of mitochondrial diseases, potentially improving patient outcomes.
How similar studies have gone: While the specific mechanisms being studied are not well-established, there is ongoing research into mitochondrial DNA maintenance, suggesting potential for breakthroughs in understanding these complex disorders.
Where this research is happening
-
University of North Florida
Jacksonville, United States Active
Researchers
- Principal investigator: Ciesielski, Grzegorz Leszek — University of North Florida
- Study coordinator: Ciesielski, Grzegorz Leszek
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.