Understanding how mitochondrial DNA deletions affect aging and cell function
Official title: Investigating the impact and dynamic of mitochondrial common deletion in somatic cells
Funded at Sloan-Kettering Inst Can Research · NIH-11126747 · Data updated 2026-11-12
This study is looking at a common change in mitochondrial DNA that may be connected to aging and diseases, and it's for anyone interested in how this change affects brain and muscle cells as we get older.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 30, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $532,067 |
| NIH project number | 5R01AG085782-03 |
| Project ID | NIH-11126747 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related diseases or conditions linked to mitochondrial dysfunction.
✕Less likely to help
Patients with acute mitochondrial disorders unrelated to aging may not benefit from this research.
What this research studies
This research investigates a specific mitochondrial DNA deletion known as the common deletion, which is linked to aging and various diseases. The study aims to understand how this deletion affects different types of cells, particularly in the brain and muscles, by using advanced genetic tools to manipulate mitochondrial DNA in controlled settings. Researchers will create specific levels of this deletion in stem cells and observe the consequences on cellular aging and function. This approach could reveal important insights into why certain cells are more vulnerable to mitochondrial damage as we age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating age-related diseases by targeting mitochondrial dysfunction.
How similar studies have gone: Previous research has shown promising results in understanding mitochondrial dysfunction in aging, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Sfeir, Agnel — Sloan-Kettering Inst Can Research
- Study coordinator: Sfeir, Agnel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.