Understanding how mitochondrial DNA affects health and aging
Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources
['FUNDING_U01'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10856918
This study is looking at how tiny parts of our cells called mitochondrial DNA might affect our health as we age and how they relate to diseases like heart problems and brain disorders, with the goal of creating better ways to understand these changes in different people.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10856918 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitochondrial DNA (mtDNA) in health and disease, particularly as it relates to aging and various diseases. By analyzing single-cell datasets, the study aims to develop new tools for examining mtDNA, which is often overlooked in current analyses. The research will explore how specific mtDNA variants accumulate over time and their impact on cellular function across different cell types and demographics. This could lead to a better understanding of how mtDNA mutations contribute to diseases like cardiovascular issues and neurodegeneration.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing aging-related diseases, particularly those with a family history of mitochondrial disorders or cardiovascular diseases.
Not a fit: Patients with conditions unrelated to mitochondrial function or aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for aging-related diseases and mitochondrial disorders.
How similar studies have performed: Previous research has shown that analyzing mitochondrial DNA can provide valuable insights into various diseases, suggesting that this approach has potential for success.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PEI, LIMING — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: PEI, LIMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.