Understanding how mitochondrial DNA affects health and aging
Novel biological insights by utilizing mitochondrial genome information from HuBMAP resources
This study is looking at how changes in tiny parts of our cells called mitochondrial DNA might affect our health as we age and with certain diseases, and it's for anyone interested in understanding more about conditions like heart problems and immune disorders.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10844787 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial DNA (mtDNA) in health and disease, particularly as it relates to aging and various disorders. By analyzing single-cell datasets, the study aims to uncover how specific mtDNA mutations accumulate over time and their impact on cellular function across different cell types and demographics. The research will develop new tools for analyzing mtDNA data, which is often overlooked in current studies, to provide deeper biological insights into diseases like cardiovascular issues and immune disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals experiencing aging-related diseases, mitochondrial disorders, or those interested in the genetic factors influencing their health.
Not a fit: Patients with conditions unrelated to mitochondrial function or aging may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for aging-related diseases and mitochondrial disorders.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial DNA's role in health, but this approach aims to fill significant gaps in knowledge, making it a novel investigation.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Pei, Liming — Children's Hosp of Philadelphia
- Study coordinator: Pei, Liming
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.