Understanding how mitochondrial DNA affects Alzheimer's Disease and aging
Quantifying the contributions of mitochondrial DNA to Alzheimer's Disease and related conditions of aging
This study is looking at how changes in the DNA passed down from mothers might affect the risk of developing Alzheimer's and other age-related conditions, and it could help patients understand how their genetics play a role in their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-10269143 on NIH RePORTER |
What this research studies
This research investigates the role of mitochondrial DNA (mtDNA) in Alzheimer's Disease and related aging conditions. By developing a unique model that leverages the maternal inheritance of mtDNA, the study aims to quantify how variations in mtDNA contribute to these diseases. The research will analyze data from a large sample of nearly 4.8 million individuals over multiple generations, linking genetic information with medical records to uncover potential connections. Patients may benefit from insights into how their genetic makeup influences their risk for Alzheimer's and related conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's Disease or related conditions, particularly those with maternal relatives affected by these diseases.
Not a fit: Patients without a family history of Alzheimer's Disease or those who do not have mitochondrial DNA variations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of genetic factors in Alzheimer's Disease, potentially guiding personalized treatment strategies.
How similar studies have performed: While the specific approach of leveraging mtDNA in this context is novel, previous research has shown that genetic factors play a significant role in Alzheimer's Disease, indicating potential for success.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Burt, S. Alexandra — Michigan State University
- Study coordinator: Burt, S. Alexandra
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.