Understanding how mitochondrial calcium affects lung cell regeneration
Official title: Linking Mitochondrial Calcium to Histone Methylation Underlying Lung Regeneration
Funded at Temple Univ of the Commonwealth · NIH-10901216 · Data updated 2026-11-12
This study is looking at how lung cells heal and grow back after injury, especially how certain proteins and calcium in the cells help this process, which could lead to new treatments for people with chronic lung diseases.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 16, 2024 |
| Project end | September 15, 2027 |
| Funding year | 2024 |
| Award (this year) | $35,481 |
| NIH project number | 1F30HL174158-01 |
| Project ID | NIH-10901216 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients suffering from chronic respiratory diseases, particularly those experiencing impaired lung healing.
✕Less likely to help
Patients with acute respiratory conditions or those without chronic lung diseases may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms that regulate lung cell regeneration, particularly focusing on how mitochondrial calcium influences the differentiation of lung cells after injury. The study aims to explore the role of specific proteins and metabolites in promoting the transition from damaged alveolar epithelial cells to healthy ones. By utilizing advanced techniques like CRISPR and ATAC sequencing, researchers will analyze cellular processes that could lead to new treatment strategies for chronic respiratory diseases. Patients with chronic lung conditions may benefit from insights gained about lung healing and regeneration.
Why it matters
Potential benefit: If successful, this research could lead to novel therapies that enhance lung regeneration in patients with chronic respiratory diseases.
How similar studies have gone: Other research has shown promising results in understanding cellular mechanisms of lung regeneration, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Pantuck, Morgan — Temple Univ of the Commonwealth
- Study coordinator: Pantuck, Morgan
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.