Understanding how mitochondrial calcium affects cell functions
Official title: Mitochondrial Calcium Uniporter in Signaling and Dynamics
Funded at Thomas Jefferson University · NIH-10927432 · Data updated 2026-11-12
This study is looking at how a special channel in our cells helps manage calcium levels, which is important for energy and communication within the cell, and it hopes to find out how problems with this process might be linked to diseases like cancer, so that patients can learn more about their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | September 15, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $421,776 |
| NIH project number | 5R01GM151536-02 |
| Project ID | NIH-10927432 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to mitochondrial dysfunction, such as certain cancers or ischemia-reperfusion injuries.
✕Less likely to help
Patients with conditions unrelated to mitochondrial function or calcium signaling may not benefit from this research.
What this research studies
This research investigates the role of mitochondrial calcium uptake in regulating various cell functions, including energy metabolism and signaling. It focuses on a specific channel, the mitochondrial calcium uniporter (mtCU), which is activated during calcium signals in the cytoplasm. By studying the components of mtCU and their interactions, the research aims to uncover how changes in calcium signaling can impact cell health and contribute to diseases like cancer. Patients may benefit from insights gained about how mitochondrial dysfunction relates to their conditions.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases linked to mitochondrial dysfunction.
How similar studies have gone: Other research has shown promising results in understanding mitochondrial calcium signaling, indicating that this approach has potential for significant findings.
Where this research is happening
-
Thomas Jefferson University
Philadelphia, United States Active
Researchers
- Principal investigator: Hajnoczky, Gyorgy — Thomas Jefferson University
- Study coordinator: Hajnoczky, Gyorgy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.